Autophagy Attenuates Noise-Induced Hearing Loss by Reducing Oxidative Stress
نویسندگان
چکیده
منابع مشابه
JAK2/STAT3 Inhibition Attenuates Noise-Induced Hearing Loss
Signal transducers and activators of transcription 3 (STAT3) is a stress responsive transcription factor that plays a key role in oxidative stress-mediated tissue injury. As reactive oxygen species (ROS) are a known source of damage to tissues of the inner ear following loud sound exposure, we examined the role of the Janus kinase 2 (JAK2)/STAT3 signaling pathway in noise induce hearing loss us...
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Noise-induced hearing loss (NIHL) is one of the most common sensorineural hearing deficits. Recent studies have demonstrated that the pathogenesis of NIHL is closely related to ischemia-reperfusion injury of cochlea, which is caused by blood flow decrease and free radical production due to excessive noise. This suggests that protecting the cochlea from oxidative stress is an effective therapeut...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2015
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2014.6004